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apalutamide will decrease the extent or effect of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with drugs which might be CYP2C19 substrates may lead to decreased exposure to these remedies.Result of coadministration of a twin CYP3A4 and CYP2